In vivo bioluminescence imaging system at UCSF

Definition
An image acquisition instrument that is designed for non-invasive in vivo use, to detect bioluminescence, which is based on the expression of luciferase, the light-emitting enzyme of the firefly Photinus pyralis. After the administration of the substrate luciferin, an ATP- and O2-dependent photochemical reaction occurs, resulting in the release of photons by living cells containing luciferase. This photon emission can be detected by a cooled charge-coupled device (CCD) camera, minutes after the administration of the substrate.
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Mission Bay, Mt. Zion

Cancer Center Preclinical Therapeutics Core

Helen Diller Family Comprehensive Cancer Center, Mission Bay, Mt. Zion
Contact: Byron Hann 415-476-0419 Byron.Hann@ucsf.edu

  • Bioluminescent imaging
  • Xenogen IVIS 100 imaging
  • Xenogen IVIS SPECTRUM imaging
Parnassus

Biological Imaging Development Center

Department of Pathology, Parnassus
Contact: Kaitlin Corbin 415-476-4550 kaitlin.corbin@ucsf.edu

  • Xenogen IVIS SPECTRUM Imager
SFGH, Parnassus, China Basin, Mt. Zion

Brain Tumor Research Center Pre-clinical Therapeutic Testing Core

Neurological Surgery, SFGH, Parnassus, China Basin, Mt. Zion
Contact: Tomoko Ozawa 415-476-9756 tomoko.ozawa@ucsf.edu

  • Xenogen